Trade name of the drug: Albendex

Active ingredient (INN): albendazole

Dosage form: tablets

Ingredients :

in one tablet contains :

Active ingredient: albendazole – 400.0 mg;

In auxiliary substances: corn starch, gelatin, sodium lauryl sulfate, sodium starch glycolate, crospovidone, microcrystalline cellulose, sodium saccharinate, croscarmellose sodium, magnesium stearate, shell coating “Instacoat Aqua”

Description:

Tablet in the form of a capsule, coated from light reddish brown to dark reddish brown biconvex film coat, with a break line on one side and smooth on the other side

Pharmacotherapeutic group: Anthelmintic agent .

ATH code: P02CA03

 

Pharmacological actions

The drug exhibits anthelmintic activity. Albendazole affects the polymerization of β-tubulin, stops it. As a result, there is a violation of the formation of microtubules in the intestines of helminths, the ability of worms to absorb glucose is suppressed, the normal intracellular migration of organelles, and the synthesis of ATP in their muscle tissue are blocked. The creation of a therapeutic concentration of albendalosis leads to the death of helminths.

The drug is active against adults and larval forms. Albendazole causes the death of nematodes (Necatoramericanus, Strongyloidesstercoralis, Enterobiusvermicularis, Trichuristrichiura, Ascarislumbricoides, Cutaneous Larva Migrans, Ancylostomaduodenale), cestodes (porcine, bovine and dwarf chainworms), trematodes

 

Indications for use

Albendazole is prescribed for:

– neurocysticercosis;

– echinococcosis of the peritoneum, liver, lungs;

– contraindications to surgery for cystic echinaccoccosis;

– the need for surgical intervention for cystic echinaccoccosis to reduce the number of cysts;

– arachnoid, intragastric, racemose cysts;

– ascariasis;

– trichonosis;

– enterobiasis;

– hookworm disease;

– opisthorchiasis;

– giardiasis;

– microsporidosis;

– toxocariasis;

– gnatostomosis;

– trichinosis;

– capillarosis;

– mixed helminthiasis.

 

Method of administration and dosage

Albendazole is prescribed orally, after meals. The tablets are washed down with water. The table shows dosages depending on the pathology. Taking laxatives after taking Albendazole is not necessary.

 

Pathology	Dosage per day	Number of days
Common helminthiases	400 mg (children – 60 mg / 10 kg)	Once
Cysticercosis of the brain	800 mg (children – 15 mg / kg)	8-30 days
Strongyloidiasis and cestodes	400 mg (200 mg)	3 days with repetition after 3 weeks
Ascariasis	400 mg (200 mg)	One-time with repetition through 3 weeks
Enterobiasis	400 mg (200 mg)	One-time with repetition through 3 weeks
Hookworm	400 mg (200 mg)	One-time with repetition through 3 weeks
Giardiasis	400 mg (200 mg)	3 days with repetition after 3 weeks

 

Side effects

Taking Albendazole may be accompanied by undesirable effects:

– leukopenia;

– pancytopenia;

– headache;

– thrombocytopenia;

– agranulocytosis;

– dyspepsia;

– an increase in the activity of liver transaminases;

– abdominal pain;

– dizziness;

– meningeal symptoms;

– every itch;

– hyperthermia;

– urticaria;

– alopecia (reversible);

– hypertension;

– impaired renal function.

 

 

 

Contraindications

Albendazole is not prescribed for:

– helminthiasis in children under 2 years of age;

– hypersensitivity to albendazole;

– pregnancy;

– lactation.

With caution when:

– pathologies of the retina against the background of cysticercosis;

– cirrhosis of the liver;

– oppression of bone marrow hematopoiesis.

Pregnancy: Albendazole is categorically contraindicated in pregnancy, suspected pregnancy.

 

Drug interactions

The plasma concentration of albendazole is increased by praziquantel, dexamethasone, cimetidine.

 

Overdose

Excessive doses are characterized by an increase in side symptoms.

 

special instructions

Keep out of reach of children and do not use after the expiration date indicated on the package.

 

Release form 

1 tablet in a blister strip.

Contoured cell packs of 1 (1 × 1), together with instructions for use, are placed in a cardboard box.

 

Storage conditions

In a dry, dark place, at a temperature not exceeding 25 ⁰ С.

 

Shelf life

3 years.

 

Conditions of dispensing from pharmacies

On prescription.