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QUPEN PLUS

Manufacturer
Well Med Pharm
Dosage form
Capsules | 500 mg
Category
Medicines
Active ingredients

Paraceatamol, caffeine

Trade name of the drug: Kupen Plus

Active ingredient (INN): paracetamol, caffeine

Dosage form: tablets

Composition:

Each tablet contains:

active substances:

paracetamol 500 mg

caffeine (anhydrous) 65 mg

excipients: starch, microcrystalline cellulose, methylparaben, propylparaben, magnesium stearate, talc, sodium starch glycolate, aerosil, croscarmellose sodium, sodium lauryl sulfate, hydroxymethylpropyl cellulose.

Description: Round, biconvex, uncoated tablets.

Pharmacotherapeutic group: Nestroid anti-inflammatory agent

By isolating ATX: M01AV55

 

Pharmacological properties

Kupen Plus is a combined medicinal product containing paracetamol and caffeine. The drug has an analgesic and antipyretic effect.

Paracetamol is a drug of a group of non-steroidal anti-inflammatory drugs that helps to reduce the level of prostaglandins in the central nervous system by inhibiting the enzyme cyclooxygenase.

Caffeine enhances the pharmacological effects of paracetamol. Paracetamol after oral administration is well absorbed in the digestive tract, the peak plasma concentration is observed 0.5-2 hours after administration.

It is metabolized in the liver. The half-life reaches from 1 to 4 hours, it is excreted mainly in the urine in the form of metabolites.

 

Indications for use

For the temporary relief of mild to moderate pain associated with migraines, headache, back pain, intermittent pain, toothache, rheumatic and muscle pain, pain without severe symptoms of arthritis, colds and flu, sore throat and fever.

 

Method of administration and dosage

Inside. For oral administration and short term use only.

The lowest effective dose should be used for the shortest time necessary to relieve symptoms. The patient should consult a physician if symptoms persist or worsen, or if the product needs to be used for more than 3 days.

Adults: take 1 tablet no more than three times a day with water. Observe at least a six-hour interval between repeated doses.

If 1 tablet does not have a therapeutic effect, you can take a maximum of 2 tablets no more than three times a day. Observe at least a six-hour interval between repeated doses.

Do not exceed 8 tablets (4000 mg paracetamol) per day.

Elderly Patients: No specific dosage modification required.

Elderly patients are at increased risk of serious adverse reactions. If NSAIDs are needed, the lowest effective dose should be used for the shortest possible time. The patient should be regularly monitored to prevent gastrointestinal bleeding during NSAID therapy.

 

 

Side effects

The drug is usually well tolerated by patients, in some cases, the development of these side effects is noted:

From the digestive tract: nausea, vomiting, pain in the epigastric region. In addition, altered liver enzymes and hepatotoxicity.

From the hematopoietic system: thrombocytopenia, pancytopenia, anemia, including hemolytic, sulfate hemoglobinemia and methemoglobinemia.

From the side of the central nervous system: disturbance of sleep and wakefulness, irritability and dizziness.

From the side of the cardiovascular system: hypertension, tachyarrhythmias.

Allergic reactions: skin rash, itching, urticaria, exudative erythema multiforme, Quincke’s edema, Lyell’s syndrome, anaphylactic shock.

Others: bronchospasm, hypoglycemia, hypoglycemic coma.

 

Contraindications :

This product is contraindicated in:

  • In patients with known hypersensitivity to NSAIDs, caffeine, paracetamol or any other components of the drug.
  • With severe renal and / or hepatic failure, congenital hyperbilirubinemia, deficiency of glucose-6-phosphate dehydrogenase.
  • The drug is not prescribed to patients suffering from alcoholism, diseases of the hematopoietic system (severe anemia, leukopenia), thrombophlebitis, thrombosis, atherosclerosis and hypertension.
  • The drug is not used to treat patients suffering from insomnia, glaucoma, including closed coal glaucoma, epilepsy, hyperthyroidism, cardiac conduction disorders, decompensated heart failure, coronary heart disease, prostatic hypertrophy, diabetes mellitus and acute pancreatitis.
  • The drug should not be administered to elderly patients and patients with a tendency to vasospasm.
  • The drug is contraindicated during pregnancy and lactation, as well as in children under 12 years of age.

The drug should be used with caution in patients with liver and / or kidney disease.

 

Drug interactions

The simultaneous use of the drug with monoamine oxidase inhibitors, tricyclic antidepressants and beta-adrenergic receptor blockers is contraindicated. The break in treatment between taking drugs of the group of monoamine oxidase inhibitors and the drug Panadol Extra should be at least 14 days. The absorption rate of paracetamol increases with its simultaneous use with metoclopramide and domperidone, with simultaneous use with cholestyramine it decreases. With the combined use of the drug with warfarin and other coumarin anticoagulants, the risk of bleeding increases. Barbiturates weaken the antipyretic effect of paracetamol when used in combination. Microsomal enzyme inducers, hepatotoxic drugs and isoniazid increase the toxic effect of paracetamol on the liver. When combined, the drug reduces the effectiveness of diuretics. The simultaneous use of the drug with drugs containing ethyl alcohol, as well as alcoholic beverages is contraindicated. When combined, caffeine increases the effectiveness of alpha and beta adrenergic agonists, xanthine and drugs that stimulate the central nervous system. With the simultaneous use of cimetidine, oral contraceptives and isoniazid, an increase in the effectiveness of caffeine is noted. Combined use of caffeine reduces the effectiveness of drugs that depress the central nervous system. Caffeine increases the lithium content in the blood, enhances the therapeutic effect of thyrotropic drugs and improves the absorption of ergotamine in the gastrointestinal tract. The simultaneous use of the drug with drugs containing ethyl alcohol, as well as alcoholic beverages is contraindicated. Combined use of caffeine increases the effectiveness of alpha and beta adrenergic agonists, xanthine and drugs that stimulate the central nervous system. With the simultaneous use of cimetidine, oral contraceptives and isoniazid, an increase in the effectiveness of caffeine is noted. Combined use of caffeine reduces the effectiveness of drugs that depress the central nervous system. Caffeine increases the lithium content in the blood, enhances the therapeutic effect of thyroid-stimulating drugs and improves the absorption of ergotamine in the gastrointestinal tract. The simultaneous use of the drug with drugs containing ethyl alcohol, as well as alcoholic beverages is contraindicated. When combined, caffeine increases the effectiveness of alpha and beta adrenergic agonists, xanthine and drugs that stimulate the central nervous system. With the simultaneous use of cimetidine, oral contraceptives and isoniazid, an increase in the effectiveness of caffeine is noted. Combined use of caffeine reduces the effectiveness of drugs that depress the central nervous system. Caffeine increases the lithium content in the blood, enhances the therapeutic effect of thyrotropic drugs and improves the absorption of ergotamine in the gastrointestinal tract. When combined, caffeine increases the effectiveness of alpha and beta adrenergic agonists, xanthine and drugs that stimulate the central nervous system. With the simultaneous use of cimetidine, oral contraceptives and isoniazid, an increase in the effectiveness of caffeine is noted. Combined use of caffeine reduces the effectiveness of drugs that depress the central nervous system. Caffeine increases the lithium content in the blood, enhances the therapeutic effect of thyrotropic drugs and improves the absorption of ergotamine in the gastrointestinal tract. Combined use of caffeine increases the effectiveness of alpha and beta adrenergic agonists, xanthine and drugs that stimulate the central nervous system. With the simultaneous use of cimetidine, oral contraceptives and isoniazid, an increase in the effectiveness of caffeine is noted. Combined use of caffeine reduces the effectiveness of drugs that depress the central nervous system. Caffeine increases the lithium content in the blood, enhances the therapeutic effect of thyroid-stimulating drugs and improves the absorption of ergotamine in the gastrointestinal tract. Combined use of caffeine reduces the effectiveness of drugs that depress the central nervous system. Caffeine increases the lithium content in the blood, enhances the therapeutic effect of thyroid-stimulating drugs and improves the absorption of ergotamine in the gastrointestinal tract. Combined use of caffeine reduces the effectiveness of drugs that depress the central nervous system. Caffeine increases the lithium content in the blood, enhances the therapeutic effect of thyrotropic drugs and improves the absorption of ergotamine in the gastrointestinal tract.

 

special instructions

In the case of prolonged use of high doses, monitoring of the blood picture is necessary.

Excessive consumption of tea and coffee is not recommended while taking the drug, as this can lead to agitation, insomnia, tachycardia, cardiac arrhythmias.

To avoid liver toxicity, paracetamol should not be combined with alcoholic beverages, and it is also not recommended for people prone to chronic alcohol consumption.

Patients with atopic asthma and hay fever have an increased risk of developing allergic reactions.

May alter the results of athletes’ drug testing.

Pregnancy and lactation

The use of the drug during pregnancy is possible only for health reasons. If it is necessary to use the drug during lactation, the issue of temporary interruption of breastfeeding should be resolved.

Influence on the ability to drive and use machinery

Side effects such as dizziness, drowsiness, fatigue and visual disturbances are possible after taking NSAIDs. Therefore, patients receiving treatment with this drug should not drive a car or work with equipment.

 

Overdose

In case of an overdose of the drug, the development of nephrotoxic and hepatotoxic effects of the drug, as well as the development of disorders from the hematopoietic system (anemia, thrombocytopenia, pancytopenia, leukopenia, neutropenia, agranulocytosis) and the central nervous system (increased excitability, dizziness, disturbed sleep and wakefulness, tremor) … In addition, the development of tachyarrhythmias, seizures, pallor of the skin, vomiting, hepatonecrosis, disorders of glucose metabolism and metabolic acidosis is possible. In case of an overdose, gastric lavage, intake of enterosorbents and symptomatic therapy are indicated. In case of severe overdose, intravenous administration of N-acetylcysteine ​​and oral administration of methionine are indicated (if the patient does not vomit). If seizures develop, diazepam is used.

 

Release form

Tablets 65 mg / 500 mg. 10 tablets in a blister pack, 10 blister packs in a cardboard box with instructions for use.

 

Storage conditions

In a dry, dark place at a temperature not exceeding 25ºC.

The drug should be kept out of the reach of children.

 

Shelf life

4 years.

Do not use after the expiration date.

 

Conditions of dispensing from pharmacies

Without recipe.

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